分类归档 hanzhen

Wang Zhongjun, Chairman of Huayi Brothers (right) and Ma Yun, founder of Alibaba (data map)

　 　 1905 movie network news On the evening of November 18th, Huayi Brothers announced that it had raised no more than 3.6 billion yuan from four issuers, including Hangzhou Ali Venture Capital Co., Ltd. (hereinafter referred to as Ali) and Shenzhen Tencent Computer System Co., Ltd. (hereinafter referred to as Tencent), through non-public issuance of A shares. Among them, 3.1 billion will be directly used to invest in film and television projects, and Huayi Brothers promised to use this fund to complete the production of 31 films within the specified three years.

　 　 In addition to the simple private placement cooperation, Huayi Brothers also revealed in two announcements on strategic cooperation that the company will carry out mutual and deep cooperation with Ali and Tencent respectively, including Taobao, Entertainment Treasure, tencent games and other platforms. In addition, Huayi also reached an agreement with these two issuers to release a certain amount of investment in "Huayi Film Works" for their participation.

　 　 So far, Huayi Brothers has completed the largest financing business in the film industry in 2014. With this issuance, Huayi successfully joined hands with companies such as Ali and Tencent, further promoting the company’s layout in the Internet field.

Huayi financing 3.1 billion: 31 films completed in 3 years.

Ali and Tencent each received 10% of the shares.

　 　 For some time, the discussion about Huayi’s "de-filmization" strategy has continued to ferment. Some people are optimistic about using this method to expand the territory and realize industrial integration; Some people think that Huayi is "doing nothing", which leads to a decline in performance. Now it is announced that it has reached strategic cooperation with Internet companies Ali, Tencent, Ping An Asset Management Co., Ltd. and CITIC Construction Securities Co., Ltd. from the financial industry. Huayi’s move can be described as "killing two birds with one stone": not only did it not neglect the original multi-layout plan, it successfully broadened the company’s resource channels in film and television, games, e-commerce, finance and other fields, but also raised 3.1 billion yuan for film and television project production, which provided a solid guarantee for the company’s next big move in film and television. According to the analysis report on the use of raised funds issued by Huayi, the company promised to use this fund to invest and produce movies and TV series in the three years from January 2015 to December 2017. Among them, there are 31 films, and the investment will account for nearly 60% of the total, including 12 super-large films, 12 large-scale films and 7 small and medium-sized films.

　 　 Among the four companies participating in this non-public offering subscription, the cooperation between Ali and Tencent, two companies from the Internet industry, and Huayi is far from simple private placement. In addition to the deep cooperation with the superior resource "new media" platform, Huayi also reached an agreement with them to release 5%-10% of total investment of the project’s "Huayi Film Works" for Ali and Tencent to participate in the project, and completed the production and distribution of five films with the two companies within three years from the effective date of the agreement.

Join hands with Ali: Entertainment Bao participates in the operation of 10 Huayi projects.

Taobao takes the lead in derivatives promotion platform.

　 　 Ali plans to subscribe for Huayi shares this time for 1.533 billion yuan, accounting for 42.5% of the total amount raised. It is not difficult to see from the strategic cooperation announcement that the cooperation between the two parties involves many aspects of the company’s business. First of all, Huayi’s film works will officially enter Ali’s "Entertainment Treasure" in the next three years, and the two companies will jointly select 10 films and adopt this product model for production and distribution. Undoubtedly, the highly targeted business attributes and a large number of user data resources of "Entertainment Bao" will make Huayi, which has just set up a new media interactive platform and is focusing on developing a "fan economy", even more powerful.

　 　 Another cooperation is related to Ali’s most popular "Taobao". As early as 2012, Huayi began to test the water film derivative model and regarded it as a powerful performance growth point. According to statistics, in the last three years, Huayi’s movie and TV drama business and its derived income totaled more than two-thirds of the total revenue. In order to continue to focus on creating a brand-new interactive system that combines traditional media with Internet finance and e-commerce, Huayi will give priority to the cooperation of e-commerce platform with Ali on its derivatives with relevant rights. For the cooperative film [Note 4], Huayi will give priority to Taobao for online ticketing sales cooperation. The ticket sales and O2O business of Huayi’s real-life entertainment theme park will also be promoted on this platform.

Cooperation with Tencent: the priority of star IP adaptation is shared by both parties

Realize the common content of movies, literature and online games.

　 　 Compared with the multi-point cooperation with Ali, the purpose of cooperation between Huayi and Tencent is much simpler and more direct, that is, sharing the star IP resources of both parties. In the next five years, under the same conditions, Tencent must give priority to Huayi’s online games or literary works for which it enjoys relevant rights. In return, all the online games, online literature and animation adaptation rights of Huayi’s film and television works will also be given priority to Tencent. For Huayi, this seemingly independent content cooperation project also undertakes the important task of exploring new ways of cooperation between Huayi’s game business and tencent games platform, and provides help for the company’s game business that needs to be developed urgently.

　 　 Huayi has been trying to deploy its interactive entertainment business group. This time, the establishment of a priority cooperation mechanism between movie IP and Tencent literature and game IP, and the opening of IP rights circulation channels between the two sides to achieve common content will help to bring into play the synergy between the company’s businesses, provide great impetus for the company to establish an internet entertainment network ecosystem, and help enterprises further improve the industrial chain layout.

[Note 1] Private placement: that is, non-public offering, offering shares to specific investors, which is also commonly known as private placement.

[Note 2] Huayi’s film works refer to film projects which are developed and produced by Huayi, controlled by Huayi, and which enjoy the decision-making power of investment arrangement.

[Note 3] Derivatives of which Huayi enjoys relevant rights: including the related derivatives of its contracted artists developed by Huayi and enjoying relevant rights, and the derivatives of which Huayi enjoys the right to develop related derivatives.

[Note 4] Huayi and Ali co-produced films: namely, 10 entertainment treasure co-produced films, 5 co-produced and distributed films and Ali participated in the film.

Original pediatric doctor Yan, pediatric doctor Yan

When I meet a baby with cough and wheezing, the first thing I think of is bronchiolitis (also called bronchiolitis), especially in winter and spring clinics.

Although bronchiolitis is not strictly pneumonia, it is difficult to manage, which is mainly related to its special lesion location and pathogenic pathogens.

01

bronchiolitis

The bronchioles are located at the end of the bronchi (below ⑤, close to the alveolar ducts), and then down are the alveolar ducts and alveoli.

The respiratory tract of young children (especially infants under one year old) is relatively narrow, and local inflammation and exudation of bronchioles can easily cause lumen blockage, hinder air from entering and leaving alveoli, and even lead to hypoxia and dyspnea in severe cases.

The symptoms of children with bronchiolitis have their own characteristics, so that clinical diagnosis can be made through symptoms and signs.

Early symptoms are mild, such as runny nose, stuffy nose, cough, and some have low fever, just like the common cold.

Different from the common cold, children with bronchiolitis have frequent cough and asthma in about 2-3 days, some have shortness of breath and inspiratory depression, and some have severe dyspnea.

Then there is a long recovery period.

Although most children can recover by themselves (the course of disease is self-limited), some need hospitalization management and even use ventilator because of severe respiratory distress.

Bronchiolitis is mostly caused by virus infection, and there is usually no targeted antiviral drug, so it can only be treated symptomatically, and then the child can carry it by himself.

The main management measures include cleaning nasal secretions, ensuring liquid intake, high-flow oxygen inhalation and auxiliary ventilation when necessary.

Aerosol inhalation of bronchodilators (salbutamol, bricanyl) and corticosteroids (budesonide) has no obvious effect on bronchiolitis, and it is usually not routinely used continuously. Unless it is observed that the symptoms of cough and asthma in children are obviously relieved after atomization inhalation, they can continue, otherwise it is recommended to stop.

It is precisely because the drug treatment of bronchiolitis is limited, so the focus of management is not how to give drugs to children, but to guide parents.

For example, guide parents to care at home, observe the progress of the disease, identify severe cases, and let parents know that the next course of disease may be longer, so they must be psychologically prepared. Otherwise, children will face excessive intervention.

02

Significance of pathogen detection

Respiratory syncytial virus (RSV) is the most common pathogen causing bronchiolitis. In addition, rhinovirus, human metapneumovirus, parainfluenza virus, adenovirus and mycoplasma pneumoniae infection can all cause bronchiolitis.

If the child has typical bronchiolitis symptoms, it is unnecessary to check the pathogen. Because even if the pathogen is known, there is usually no antiviral method. But many times, I will choose to check.

Why check? Mainly to facilitate communication with parents.

For example, cough and asthma in children with bronchiolitis lasts for a long time, which may be several weeks, and has no obvious expected effect on many treatment methods including atomized inhalation. In this case, parents are inevitably anxious.

Parents are anxious and will try their best to control their children’s symptoms. They may take their children to see a doctor repeatedly, and the children will face more medication. In addition, repeated exposure to medical institutions will increase the risk of nosocomial infection.

And a clear result of pathogenic examination (such as detecting a virus) can alleviate parents’ anxiety to a certain extent and facilitate communication between doctors and patients.

Therefore, in the clinic, when a child is suspected of bronchiolitis, I usually suggest a rapid antigen test for nasopharyngeal swab RSV first (RSV is chosen because it is the most likely and the rapid antigen test is very convenient).

If it is positive, inform the parents of the main points of home management, the possibility of facing a longer course of disease, and avoiding the abuse of antibiotics during this period, so that parents can be mentally prepared.

You see, proper auxiliary examination is actually to protect children.

However, RSV is only the most common virus that causes bronchiolitis. At work, children with typical bronchiolitis symptoms will also be encountered, but RSV is negative. How to manage it?

03

A case

Next, share a case. Before sharing, as usual, I would like to thank my parents for their permission.

This 11-month-old baby was the last patient on the afternoon of December 1st. Before coming to my clinic, the course of cough was nearly ten days, and I have been treated twice in other hospitals. In the clinic, the child coughed violently and vomited several times, with obvious asthma, shortness of breath and inspiratory depression, and fever.

Hormones and bronchodilators have been atomized and inhaled at home, and the symptoms are not obviously relieved.

I did a rapid RSV antigen test first, and the result was negative.

Although the child has shortness of breath and inspiratory depression, the degree is not serious and the oxygen saturation is still in the normal range.

Although coughing leads to vomiting and affects eating, there is no dehydration;

Although low fever, but the overall state is not bad, willing to interact with others, no symptoms of infection and poisoning;

Most importantly, my mother has a certain ability to observe the changes of diseases. Although she is anxious, she is not particularly anxious.

I evaluate that the child has not reached the indication of hospitalization at present, and there is no clear manifestation of bacterial infection. The high probability is still viral infection. After taking a throat swab sample and doing targeted sequencing, he didn’t prescribe medicine, so he was told to go home for observation and follow up online. I also repeatedly reminded that if the symptoms get worse, I need to be hospitalized.

To tell the truth, when the patient’s family was ready to leave the clinic after the visit, I was really sorry when my mother asked the children to wave goodbye to me. Coming from other places, the total cost of consultation and laboratory test is more than 1,500 yuan. I didn’t prescribe any medicine, and I didn’t know the pathogen. I went home empty-handed, and the future course of my illness is still unclear, which is really worrying.

On the second day, I contacted my parents by phone. The parents reported that they still coughed and vomited, but the frequency was less, my temperature was normal, I could eat something, and my urine volume was normal.

On the afternoon of the third day, targeted sequencing showed that the sample contained high concentration of human metapneumovirus, and cytomegalovirus was detected.

Combined with the symptoms of the child, I think the child is bronchiolitis caused by human metapneumovirus infection. As for the detected cytomegalovirus, it is considered to be carried in the pharynx (previous infection).

Because my home is out of town, I didn’t ask my parents to take her back to the clinic for follow-up, and I kept in touch by phone all the time.

Fortunately, the symptoms behind this child gradually eased, and it was not until mid-December that there was basically no cough, but there was phlegm in the throat from time to time. The total course of disease is more than 3 weeks, which accords with the characteristics of classic bronchiolitis.

04

Human metapneumovirus

Everyone should be unfamiliar with human metapneumovirus, and the doctor’s knowledge is likely to stay at the textbook level, because this pathogen is not checked at ordinary times and there is a lack of perceptual knowledge.

With the targeted sequencing in our outpatient department, many children were found to be infected with this virus. I thought it was a little strange at first, but if you look up the relevant information, you will find that you are rare and strange. I didn’t know it before, but I just didn’t have the ability to test it.

In 2001, Dutch virologist Bernadette G. van den Hoogen and his colleagues isolated a new virus from the respiratory secretions of 28 young children, named human metapneumovirus, hMPV).

HMPV belongs to pneumoviridae. Pneumoviridae is named because its viruses are related to respiratory diseases of people or other animals, and the most famous one is RSV.

HMPV is distributed all over the world, and is often prevalent in winter/spring in temperate regions, overlapping with RSV and flu seasons.

Serological studies show that hMPV has spread for at least 60 years. By the age of five, almost all children in the world have been infected, which is considered to be the common cause of lower respiratory tract infection in children (second only to RSV in some areas).

Although infection is common in early life, reinfection is also common in older children and adults. Reinfection is mostly mild infection, such as common cold symptoms, but the risk of serious diseases will increase when reinfection occurs in immunocompromised people or the elderly.

HMPV may be transmitted by contact with virus-containing secretions, droplets, large aerosol particles or pollutants.

05

Symptom

The symptom characteristics and severity of hMPV are similar to RSV, so I often mistake hMPV infection in children for RSV infection.

Like RSV, the common symptoms of children infected with hMPV are fever, cough, runny nose and stuffy nose, and nearly half of young children may have asthma. A few patients may have acute laryngitis.

If hMPV only affects the upper respiratory tract, the symptoms are like common cold, such as mild fever, runny nose, stuffy nose, sore throat, cough and headache, which usually disappear in about a week.

However, hMPV is not very friendly to children and the elderly, and may spread to the lower respiratory tract. Infants infected with hMPV are prone to bronchiolitis, and the symptoms described in the first part of this paper, "Bronchiolitis", appear.

Some children with hMPV infection need hospitalization because of severe respiratory distress or inability to eat effectively with dehydration.

06

Severe risk

The risk of severe illness and hospitalization is significantly increased in the following groups:

Premature infants (gestational age ≤36 weeks)

Low birth weight infants (birth weight less than 2500g)

Infants under 1 year old

Chronic lung diseases (especially bronchopulmonary dysplasia)

Abnormal anatomical structure of airway

Congenital heart disease (with significant hemodynamic abnormalities)

Immune hypofunction

Nervous system diseases

Children with these high-risk factors need special attention, because their risk of adverse outcomes is significantly increased.

07

Treatment

Symptomatic treatment.

Use antipyretics to relieve discomfort caused by fever.

Clean nasal secretions to make children more comfortable and easy to eat and sleep.

Ensure liquid and energy intake and avoid dehydration.

Respiratory support: oxygen, assisted breathing.

Antiviral treatment.

Ribavirin and other antiviral drugs have been shown to be active against hMPV in vitro. However, there is no clinical data about the effect of ribavirin or other antiviral drugs on hMPV infection.

Therefore, antiviral drugs are not recommended for people infected with hMPV.

08

Epidemic vaccine

At present, there is no approved hMPV vaccine.

Moderna, an American pharmaceutical company, has developed a candidate vaccine against hMPV and conducted clinical trials.

As of October 2019, the candidate vaccine has passed the first phase of clinical trials. It is reported that the vaccine is well tolerated at all dosage levels within two months, and it stimulates immune response and produces neutralizing antibodies.

09

Total knot

Whether it is RSV, hMPV, or bronchiolitis caused by Boca virus, rhinovirus and parainfluenza virus, there is no difference in our management principles.

If you have the conditions to check, you can check the cause and find out hMPV, so don’t worry too much; If there is no condition to check, it can be diagnosed by symptoms and managed according to bronchiolitis.

The focus of management is still home care and observing the progress of the disease.

Original title: "Cough, asthma and fever, thought it was RSV infection, the result was human metapneumovirus, what should I do?" 》

Read the original text

The Top Tens is the largest poll website in the United States, with more than 90,000 groups of voting topics and more than 30 million people voting, involving social news, entertainment, movies, music, shopping, tourism and other fields. Its status can be regarded as a "review" in Europe and America. In such a mature automobile consumption market in Europe and America, their comments on it are considered worthy of reference. Look at the top three brands of "Best Motor Oil Brands", and there are brand-specific comments to let you know why it is popular!

No.1 USA shengpai

As the first lubricating oil brand in the world, the deep accumulation of 150 years history makes Shengpai engine oil have good quality. The early winning brand engine oil was the only recommended engine oil for Ford Model T, the engine oil for the first-place vehicle in the first national racing competition, and the engine oil that was widely used by allied vehicles in World War II. Now Shengpai engine oil is the pre-loaded oil of Swedish "Ghost" Koenigsegg, and the only engine oil in the world that provides 300,000 miles (480,000 kilometers) warranty.

During the extended warranty period of the engine provided by Shengpai, if the engine fails, Shengpai will compensate all the maintenance costs, which is full confidence in the anti-wear level of its oil. In the promotion of winning the brand, it was directly used that "the abrasion resistance is four times better than that of No.1", which directly led to the lawsuit with Mobil. In the end, the third-party test results confirmed that the winning card was not falsely advertised, so that official website, the winning card, still uses such an introduction, and its strength can be seen.

Nowadays, the oil giant companies with nearly 1,000 service outlets in the United States have begun to enter the domestic market. Although the popularity of the winning brand in China is not high at present, it is believed that they can get the best engine oil in THE TOP TENS, the best engine oil in Harris poll in 13 years, the best engine oil in 15 years (without voting in 14 years) and the second engine oil in 16 years, and they will certainly get a good reputation among domestic consumers in the future.

No.2 Mobil no.1

Daniel F. Akerson Mobil is the world’s largest non-governmental oil and gas producer and the world’s largest non-governmental natural gas seller; It is also one of the largest refiners in the world. Mobil No.1 is the best quality engine oil under the Mobil brand. Its unique composition is also the patented technology of Mobil, and it is the biggest highlight of Mobil No.1 engine oil.

PAO composition has the best low-temperature and high-temperature properties, shear stability and oxidation stability. It can provide good protection for the engine whether it is cold start or hot start. However, the performance of Mobil No.1 in quietness is very poor, so Mobil No.1 is more suitable for friends who love racing and noise, which is also an important reason why Mobil No.1, which has been sold in China for more than ten years, still fails to gain absolute advantage in the competition with China and Japan.

No.3

Total is currently the fourth largest oil and gas company in the world, and its corporate structure is somewhat similar to that of Mobil. As an oil company with considerable strength and history, Total’s technical strength goes without saying. TOTAL’s greatest feat in recent years is that it completed its nine-year rule with Citroen in WRC (World First Class Rally) in 2004 -12. Now Citroen has shifted its focus to Dakar Rally, and its achievements still have great dominance. Total, who is close to Citroen, played an important role in this.

However, in the domestic market, Total seems to have been tepid, and both the vague product line and the poor sales channels seem to show Total’s indifference to the domestic market. However, being unpopular in China is worthy of such market initiatives as Total. The winning brand, which was not well-known in China three years ago, has now taken a solid step in improving its product line and consumer experience. I wonder if Total can use more snacks in the domestic market?

In terms of other engine oil brands, Castrol, the three giants in China, won the fifth place, while Shell only ranked ninth, and its subsidiary Pengsi instead won the sixth place.

● Related reading:

Illegal industrial chain reveals the whole process of fake engine oil recycling and sales

Choose oil and use oil to talk about oil price. There are these points to pay attention to when using engine oil.

Note: The content of this article is reproduced from other media, please respect the copyright and keep the source, and bear all legal responsibilities. Truck House published this article for the purpose of transmitting more information, which does not mean agreeing with its views or confirming its description, nor does it mean that this website is responsible for its authenticity. If you have any questions or doubts about the content of this manuscript, please contact Truck House immediately, and this website will give you a quick response and handle it.